{"id":17964,"date":"2015-04-07T12:49:41","date_gmt":"2015-04-07T09:49:41","guid":{"rendered":"http:\/\/balarisi.org\/?p=17964"},"modified":"2015-04-08T11:15:49","modified_gmt":"2015-04-08T08:15:49","slug":"dogu-karadeniz-bolgesi-propolisinin-anti-influenza-virus-aktivitesinin-in-vitro-ve-in-vivo-degerlendirilmesi","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17964","title":{"rendered":"Do\u011fu karadeniz b\u00f6lgesi propolis\u2019inin anti-influenza vir\u00fcs aktivitesinin in vitro ve in vivo de\u011ferlendirilmesi"},"content":{"rendered":"<p><strong>Baran Tonyal\u0131<\/strong><br \/>\nY\u00fcksek Lisans Tezi, Karadeniz Teknik \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ T\u0131bbi Mikrobiyoloji Anabilim Dal\u0131, 2011, 116 s.<br \/>\nTEZ NO: <strong>310198<\/strong><br \/>\n<!--more--><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"https:\/\/tez.yok.gov.tr\/UlusalTezMerkezi\/tarama.jsp\" target=\"_blank\">Sorgu Penceresine TEZ NO&#8217;yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n<p><strong>\u00d6ZET<br \/>\n<\/strong> Propolis, farkl\u0131 bitki kaynaklar\u0131ndan toplanan maddelerin i\u015flenmesi ve ar\u0131lar taraf\u0131ndan zenginle\u015ftirilmesi sonucu elde edilen re\u00e7inemsi bir maddedir. \u0130nfluenza, akut, bula\u015f\u0131c\u0131 ve epidemiler \u015feklinde g\u00f6r\u00fclen bir solunum sistemi hastal\u0131\u011f\u0131d\u0131r. K\u00fc\u00e7\u00fck \u00e7ocuklardan ya\u015fl\u0131lara kadar uzanan geni\u015f bir ya\u015f b\u00f6l\u00fcm\u00fcn\u00fc etkiler. Propolisin \u00f6zel olarak influenza vir\u00fcs\u00fcne kar\u015f\u0131, in vitro ve in vivo etkinli\u011fi \u00fczerinde, literat\u00fcr ara\u015ft\u0131rmas\u0131 ile ortaya \u00e7\u0131kar\u0131labilen s\u0131n\u0131rl\u0131 say\u0131da \u00e7al\u0131\u015fma bulunmaktad\u0131r. Bu \u00e7al\u0131\u015fmada Do\u011fu Karadeniz B\u00f6lgesi Propolisi\u2019nin etanoll\u00fc ve sulu ekstraktlar\u0131n\u0131n 100 ? 0.78\u00b5g\/ml konsantrasyonlar\u0131n\u0131n in vitro anti-influenza aktivitesi, 10mg\/kg konsantrasyonunun ise in vivo anti-influenza aktivitesi incelendi. Sulu ve etanoll\u00fc propolis ekstraktlar\u0131n\u0131n in vivo ve in vitro anti-influenza aktivitelerinin farkl\u0131 oldu\u011fu g\u00f6zlemlendi. Propolisin sulu ekstrakt\u0131 in vitro anti-influenza etkinli\u011fi g\u00f6stermezken, etanoll\u00fc ekstrakt\u0131n\u0131n 100\u00b5g\/ml ve 50\u00b5g\/ml konsantrasyonlar\u0131nda anti-influenza etkisi g\u00f6zlemlendi. Sulu ve etanoll\u00fc ekstraktlar\u0131 farelere 10mg\/kg dozda oral yoldan verilerek in vivo non-letal ve sub-letal (sa\u011f kal\u0131m deneyi) deneylerde anti-influenza aktivitesi de\u011ferlendirildi. Sulu ekstrakt\u0131n\u0131n non-letal deneyde, Balb\/c farelerin 4. g\u00fcn burun y\u0131kant\u0131lar\u0131ndaki vir\u00fcs titresini d\u00fc\u015f\u00fcrd\u00fc\u011f\u00fc g\u00f6zlendi. Etanoll\u00fc ekstrakt\u0131n\u0131n oral yoldan verildi\u011fi grupta ise titrede d\u00fc\u015fme g\u00f6r\u00fclmedi. Bu sebepten sub-letal deneyde farelere etanoll\u00fc ekstrakttan verilmesi tercih edilmedi. Sulu ekstrakt\u0131n anti-influenza etkisi sub-letal deneyde s\u0131nand\u0131. 11 fare i\u00e7eren kontrol grubundan 3 fare sa\u011f kal\u0131rken sulu ekstrakt\u0131n 10mg\/kg dozunun oral yoldan verildi\u011fi grupta 11 fareden 8\u2019inin hayatta kald\u0131\u011f\u0131 g\u00f6zlendi.<br \/>\n<strong>Anahtar Kelimeler: <\/strong> Balb\/c; Propolis; anti-influenza<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Baran Tonyal\u0131 Y\u00fcksek Lisans Tezi, Karadeniz Teknik \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ T\u0131bbi Mikrobiyoloji Anabilim Dal\u0131, 2011, 116 s. TEZ NO: 310198<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[37],"tags":[],"class_list":["post-17964","post","type-post","status-publish","format-standard","","category-yuksek-lisans-tezleri","yazarlar-baran-tonyali","anahtarkelimeler-apiterapi","anahtarkelimeler-dogu-karadeniz-bolgesi","anahtarkelimeler-influenza","anahtarkelimeler-propolis","anahtarkelimeler-propolis-ve-yoresel-arastirmalar","anahtarkelimeler-propolisin-faydalari","anahtarkelimeler-yoresel-arastirmalar"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17964","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17964"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17964\/revisions"}],"predecessor-version":[{"id":17965,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17964\/revisions\/17965"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17964"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17964"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}