{"id":17955,"date":"2015-04-07T12:35:54","date_gmt":"2015-04-07T09:35:54","guid":{"rendered":"http:\/\/balarisi.org\/?p=17955"},"modified":"2015-04-08T11:17:33","modified_gmt":"2015-04-08T08:17:33","slug":"l-name-uygulanan-sican-dokularinda-bazi-biyokimyasal-parametreler-uzerine-propolisin-etkilerinin-arastirilmasi","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17955","title":{"rendered":"L-name uygulanan s\u0131\u00e7an dokular\u0131nda baz\u0131 biyokimyasal parametreler \u00fczerine propolisin etkilerinin ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p><strong>O\u011fuz Murat Pa\u015fao\u011flu<\/strong><br \/>\nY\u00fcksek Lisans Tezi, Ni\u011fde \u00dcniversitesi \/ Fen Bilimleri Enstit\u00fcs\u00fc \/ Biyoloji Anabilim Dal\u0131, 2011, 73 s.<br \/>\nTEZ NO: <strong>297601<\/strong><br \/>\n<!--more--><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"https:\/\/tez.yok.gov.tr\/UlusalTezMerkezi\/tarama.jsp\" target=\"_blank\">Sorgu Penceresine TEZ NO&#8217;yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n<p><strong>\u00d6ZET<br \/>\n<\/strong> Bu \u00e7al\u0131\u015fmada, Wistar albino t\u00fcr\u00fc s\u0131\u00e7anlara nitrik oksit (NO) inhibit\u00f6r\u00fc olan L-NAME (N-nitro-L-arginin-metil ester) uygulanarak olu\u015fturulan oksidatif stresin giderilmesinde, propolisin koruyucu rol\u00fcn\u00fc tespit etmek amac\u0131yla, b\u00f6brek ve kalp dokular\u0131nda baz\u0131 biyokimyasal analizler yap\u0131lm\u0131\u015ft\u0131r.\u00c7al\u0131\u015fmada deney hayvanlar\u0131; kontrol, propolis, L-NAME ve L-NAME +propolis olmak \u00fczere d\u00f6rt gruba ayr\u0131lm\u0131\u015ft\u0131r.S\u0131\u00e7an b\u00f6brek dokular\u0131nda; L-NAME uygulama grubunda katalaz (CAT) aktivitesi ve malondialdehit (MDA) d\u00fczeyinde, kontrol grubuna g\u00f6re anlaml\u0131 art\u0131\u015flar belirlenirken, NO d\u00fczeyinde \u00f6nemli azalma meydana geldi (P?0.001). L-NAME + propolis grubunda ise L-NAME grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda CAT aktivitesi ve MDA miktar\u0131nda anlaml\u0131 azalmalar meydana gelirken, NO d\u00fczeyinde \u00f6nemli art\u0131\u015f oldu\u011fu g\u00f6zlendi (P?0.001). Propolis grubu CAT aktivitesi ve MDA seviyesinde kontrol grubuna g\u00f6re anlaml\u0131 azalmalar saptan\u0131rken, NO d\u00fczeyinde \u00f6nemli art\u0131\u015f g\u00f6zlendi (P?0.001).S\u0131\u00e7an kalp dokular\u0131nda; L-NAME uygulanan grupta CAT aktivitesi ve MDA miktar\u0131nda, kontrol grubuna g\u00f6re anlaml\u0131 art\u0131\u015flar (P&lt;0.01) g\u00f6zlenirken, NO seviyesinde \u00f6nemli azalma belirlendi (P=0.012). L-NAME + propolis grubunda ise L-NAME grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda CAT aktivitesi ve MDA de\u011ferinde \u00f6nemli azalmalar (P&lt;0.01) saptan\u0131rken, NO d\u00fczeyinde anlaml\u0131 art\u0131\u015f (P=0.012) oldu\u011fu tespit edildi. Propolis grubu CAT ve MDA de\u011ferlerinde kontrol grubuna g\u00f6re anlaml\u0131 azalmalar (P&lt;0.01) elde edilirken, NO miktar\u0131nda \u00f6nemli art\u0131\u015f g\u00f6zlendi (P=0.012).Elde edilen bu veriler sonucunda, NO inhibit\u00f6r\u00fc olan L-NAME uygulanm\u0131\u015f s\u0131\u00e7anlarda meydana gelen oksidatif stresin propolis taraf\u0131ndan giderilebilece\u011fi biyokimyasal analizler ile ortaya konulmu\u015ftur.<br \/>\n<strong>Anahtar Kelimeler: <\/strong> B\u00f6brek, Kalp, Katalaz (CAT), L-NAME, Malondialdehit (MDA), Nitrik oksit (NO), Oksidatif stres, Propolis, S\u0131\u00e7an<\/p>\n","protected":false},"excerpt":{"rendered":"<p>O\u011fuz Murat Pa\u015fao\u011flu Y\u00fcksek Lisans Tezi, Ni\u011fde \u00dcniversitesi \/ Fen Bilimleri Enstit\u00fcs\u00fc \/ Biyoloji Anabilim Dal\u0131, 2011, 73 s. TEZ NO: 297601<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[37],"tags":[],"class_list":["post-17955","post","type-post","status-publish","format-standard","","category-yuksek-lisans-tezleri","yazarlar-oguz-murat-pasaoglu","anahtarkelimeler-propolis","anahtarkelimeler-propolisin-faydalari"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17955","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17955"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17955\/revisions"}],"predecessor-version":[{"id":17956,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17955\/revisions\/17956"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17955"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17955"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17955"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}