{"id":17949,"date":"2015-04-07T12:31:41","date_gmt":"2015-04-07T09:31:41","guid":{"rendered":"http:\/\/balarisi.org\/?p=17949"},"modified":"2015-04-08T11:18:59","modified_gmt":"2015-04-08T08:18:59","slug":"propolisin-antimutajenik-etkilerinin-drosophila-melanogasterde-arastirilmasi","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17949","title":{"rendered":"Propolisin antimutajenik etkilerinin Drosophila melanogaster\u2019de ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"

P\u0131nar \u00d6zge \u00d6zcan<\/strong>
\nY\u00fcksek Lisans Tezi, Hacettepe \u00dcniversitesi \/ Fen Bilimleri Enstit\u00fcs\u00fc \/ Biyoloji B\u00f6l\u00fcm\u00fc \/ Genel Biyoloji Anabilim Dal\u0131, 2011, 80 s.
\nTEZ NO: 299474<\/strong>
\nSorgu Penceresine TEZ NO’yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n

\u00d6ZET
\n<\/strong> Propolis ar\u0131lar\u0131n bitki filiz ve tomurcuklar\u0131ndan toplad\u0131\u011f\u0131, kovan giri\u015f deli\u011fini, \u00e7atlak ve k\u0131r\u0131klar\u0131 kapatt\u0131\u011f\u0131, antibakteriyel, antiviral, antifungal, antioksidan, antiparazitik \u00f6zelliklere sahip yap\u0131\u015fkan ve re\u00e7ine benzeri bir maddedir. G\u0131da katk\u0131 maddeleri (GKM) ise yiyecek ve i\u00e7eceklerin \u00fcretiminde \u00e7e\u015fitli a\u015famalarda modern teknolojinin getirisi olarak s\u0131k\u00e7a kullan\u0131lmaktad\u0131r. \u00d6zellikle et ve et \u00fcr\u00fcnlerinin i\u015flenmesinde kullan\u0131lan nitrit ve nitratlar\u0131n, gastrointestinal sistemde nitrozaminler gibi \u00e7e\u015fitli \u00f6nemli karsinojenlere d\u00f6n\u00fc\u015ft\u00fc\u011f\u00fc ve mutasyona neden oldu\u011fu bilinmektedir.Bu \u00e7al\u0131\u015fmada T\u00fcrkiye\u2019nin Tekirda\u011f ilinden toplanan propolisin etanol \u00f6z\u00fct\u00fcn\u00fcn antimutajenik etkileri, GKM\u2019lerinden NaNO2 ve NaNO3\u2019\u0131n mutajenik etkilerine kar\u015f\u0131 Drosophila melanogaster\u2019de somatik mutasyon ve rekombinasyon testi (SMART) ile ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.Propolisin etanol ekstrakt\u0131n\u0131n (PEE) 5,10, 20, 40 mg\/ml\u2019lik dozlar\u0131 ile uygulamalar 2 grup halinde yap\u0131lm\u0131\u015ft\u0131r. \u0130lk grupta 2. evre larvalar\u0131na propolis \u00f6n uygulamas\u0131ndan sonra NaNO2 veya NaNO3 uygulanm\u0131\u015ft\u0131r. Di\u011fer grupta (birlikte uygulama grubu) ise 3. evre larvalar\u0131na NaNO2 veya NaNO3 ile PEE ayn\u0131 anda uygulanm\u0131\u015ft\u0131r.NaNO2 ve PEE\u2019nin birlikte uyguland\u0131\u011f\u0131 grupta PEE\u2019nin t\u00fcm dozlar\u0131 i\u00e7in klon ind\u00fcksiyon frekans\u0131nda azalma g\u00f6zlenmi\u015ftir. NaNO3 gruplar\u0131ndan PEE\u2019nin \u00f6n uygulama gruplar\u0131nda da PEE\u2019nin t\u00fcm dozlar\u0131 i\u00e7in klon ind\u00fcksiyon frekans\u0131nda anlaml\u0131 derecede d\u00fc\u015f\u00fc\u015f saptanm\u0131\u015ft\u0131r. PEE ve NaNO3\u2019\u0131n birlikte uyguland\u0131\u011f\u0131 grupta PEE\u2019nin antigenotoksik etkisinin doza ba\u011fl\u0131 olarak de\u011fi\u015fti\u011fi g\u00f6zlenmi\u015ftir. Ayr\u0131ca PEE\u2019nin antigenotoksik etkisinin, \u00f6n uygulama grubunda, birlikte uygulama grubundan daha y\u00fcksek oldu\u011fu saptanm\u0131\u015ft\u0131r. Propolisin i\u00e7eri\u011findeki maddelerin antioksidan ve serbest radikalleri yakalama \u00f6zellikleri sayesinde nitrozasyonu engellemesinden kaynaklanan g\u00fc\u00e7l\u00fc antigenotoksik etkisi, N-nitrozamin \u00f6nc\u00fcl\u00fc GKM\u2019lerinin genotoksik etkilerini \u00f6nledi\u011fi d\u00fc\u015f\u00fcn\u00fclmektedir.
\nAnahtar Kelimeler: <\/strong> Drosophila melanogaster; PEE (Propolisin etanol ekstrakt\u0131); SMART; sodyum nitra; sodyum nitrit<\/p>\n","protected":false},"excerpt":{"rendered":"

P\u0131nar \u00d6zge \u00d6zcan Y\u00fcksek Lisans Tezi, Hacettepe \u00dcniversitesi \/ Fen Bilimleri Enstit\u00fcs\u00fc \/ Biyoloji B\u00f6l\u00fcm\u00fc \/ Genel Biyoloji Anabilim Dal\u0131, 2011, 80 s. TEZ NO: 299474<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[37],"tags":[],"class_list":["post-17949","post","type-post","status-publish","format-standard","","category-yuksek-lisans-tezleri","yazarlar-pinar-ozge-ozcan","anahtarkelimeler-antimutajenik-etki","anahtarkelimeler-propolis"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17949"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17949\/revisions"}],"predecessor-version":[{"id":17950,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17949\/revisions\/17950"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}