{"id":17945,"date":"2015-04-07T12:30:43","date_gmt":"2015-04-07T09:30:43","guid":{"rendered":"http:\/\/balarisi.org\/?p=17945"},"modified":"2015-04-08T11:19:37","modified_gmt":"2015-04-08T08:19:37","slug":"streptozotozin-ile-diyabet-olusturulan-sicanlarda-propolisin-ogrenme-ve-bellek-uzerine-etkisi","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17945","title":{"rendered":"Streptozotozin ile diyabet olu\u015fturulan s\u0131\u00e7anlarda propolisin \u00f6\u011frenme ve bellek \u00fczerine etkisi"},"content":{"rendered":"

Burcu K\u00f6ksal<\/strong>
\nY\u00fcksek Lisans Tezi, \u0130n\u00f6n\u00fc \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Fizyoloji Anabilim Dal\u0131, 2011, 95 s.
\nTEZ NO: 282101<\/strong>
\nSorgu Penceresine TEZ NO’yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n

\u00d6ZET
\n<\/strong> Ara\u015ft\u0131rman\u0131n amac\u0131, streptozotozinle (STZ) deneysel olarak diyabet olu\u015fturulmu\u015f s\u0131\u00e7anlar\u0131n, a\u00e7l\u0131k kan glikoz de\u011ferlerine, eser element d\u00fczeylerine, \u00f6\u011frenme ve bellekleri \u00fczerine, propolisin etkilerini ara\u015ft\u0131rmakt\u0131r.\u00c7al\u0131\u015fmada 51 adet, erkek, Sprague Dawley cinsi s\u0131\u00e7an kullan\u0131ld\u0131. Bellek ve \u00f6\u011frenme de\u011ferlendirmeleri i\u00e7in d\u00f6rt hafta boyunca, s\u0131\u00e7anlara 8 kollu labirent uygulamalar\u0131 yap\u0131ld\u0131. \u00c7al\u0131\u015fma; kontrol (K) (n=14), STZ uygulanan (STZ) (n=12), STZ uygulamas\u0131ndan \u00f6nce propolisin verilen (P+STZ) (n=12), STZ uygulamas\u0131ndan sonra propolis verilen (STZ+P) (n=13) grup olmak \u00fczere tasarland\u0131.\u00c7al\u0131\u015fmada latent (gizil) \u00f6\u011frenme, k\u0131sa ve uzun s\u00fcreli bellek hatalar\u0131, bellek g\u00f6revi i\u00e7in harcanan zaman de\u011fi\u015fkenlerine odaklan\u0131ld\u0131. Ayr\u0131ca, a\u00e7l\u0131k kan glikoz d\u00fczeylerine, a\u011f\u0131rl\u0131k de\u011fi\u015fimlerine, serumdaki iz elementlere ve oksidatif stres d\u00fczeyindeki enzim aktivitelerine bak\u0131ld\u0131.Ara\u015ft\u0131rman\u0131n bulgular\u0131na g\u00f6re, STZ grubunda a\u00e7l\u0131k kan glikoz seviyesinin di\u011fer gruplara g\u00f6re y\u00fcksek de\u011ferlere sahip oldu\u011fu, propolis uygulamas\u0131 ile a\u00e7l\u0131k kan glikoz d\u00fczeylerinde d\u00fc\u015f\u00fc\u015f oldu\u011fu belirlendi. STZ grubundaki s\u0131\u00e7anlarda, v\u00fccut a\u011f\u0131rl\u0131klar\u0131nda azalma belirlendi. Ayr\u0131ca; Zn2+ d\u00fczeylerinde, propolis uygulanan gruplarda, anlaml\u0131 bir art\u0131\u015f\u0131n oldu\u011fu g\u00f6r\u00fcld\u00fc. Di\u011fer iz elementler ve oksidatif stres enzim aktiviteleri a\u00e7\u0131s\u0131ndan, gruplar aras\u0131nda herhangi bir farkl\u0131l\u0131k bulunmad\u0131. Bellek de\u011ferlendirmelerinde, en fazla k\u0131sa s\u00fcreli bellek hatas\u0131n\u0131 STZ grubundaki s\u0131\u00e7anlar\u0131n yapt\u0131\u011f\u0131, en fazla uzun s\u00fcreli bellek hatas\u0131n\u0131 ise P+STZ grubundaki s\u0131\u00e7anlar\u0131n yapt\u0131\u011f\u0131 g\u00f6r\u00fcld\u00fc. En az k\u0131sa s\u00fcreli ve en az uzun s\u00fcreli bellek hatas\u0131n\u0131, STZ+P grubundaki s\u0131\u00e7anlar g\u00f6sterdi. Ayr\u0131ca, sadece STZ uygulanan diyabetik s\u0131\u00e7anlar\u0131n, labirentte daha fazla zaman harcamalar\u0131na ra\u011fmen daha az say\u0131da toplam kol ve do\u011fru kola girdi\u011fi belirlendi. Ancak, propolis uygulanan gruplar\u0131n, kontrol grubuna yak\u0131n de\u011ferlerde toplam kola girdi\u011fi ve girdikleri do\u011fru kol say\u0131s\u0131n\u0131n da kontrole benzer de\u011ferlerde oldu\u011fu g\u00f6r\u00fcld\u00fc.
\nAnahtar Kelimeler: <\/strong> Bellek; Diyabet; Propolis; Sekiz Kollu Labirent; Streptozotosin; \u00d6\u011frenme<\/p>\n","protected":false},"excerpt":{"rendered":"

Burcu K\u00f6ksal Y\u00fcksek Lisans Tezi, \u0130n\u00f6n\u00fc \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Fizyoloji Anabilim Dal\u0131, 2011, 95 s. TEZ NO: 282101<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[37],"tags":[],"class_list":["post-17945","post","type-post","status-publish","format-standard","","category-yuksek-lisans-tezleri","yazarlar-burcu-koksal","anahtarkelimeler-propolis"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17945","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17945"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17945\/revisions"}],"predecessor-version":[{"id":17946,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17945\/revisions\/17946"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17945"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}