{"id":17943,"date":"2015-04-07T12:30:17","date_gmt":"2015-04-07T09:30:17","guid":{"rendered":"http:\/\/balarisi.org\/?p=17943"},"modified":"2015-04-08T11:19:56","modified_gmt":"2015-04-08T08:19:56","slug":"propolisin-etanolik-ekstresinin-helicobacter-pylori-ye-karsi-antimikrobiyal-etkisinin-arastirilmasi","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17943","title":{"rendered":"Propolisin etanolik ekstresinin hel\u0131cobacter pylor\u0131 ye kar\u015f\u0131 antimikrobiyal etkisinin ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p><strong>Ersin Karabulut<\/strong><br \/>\nY\u00fcksek Lisans Tezi, Erciyes \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Farmas\u00f6tik Mikrobiyoloji Anabilim Dal\u0131, 2011, 62 s.<br \/>\nTEZ NO: <strong>311436<\/strong><br \/>\n<!--more--><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"https:\/\/tez.yok.gov.tr\/UlusalTezMerkezi\/tarama.jsp\" target=\"_blank\">Sorgu Penceresine TEZ NO&#8217;yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n<p><strong>\u00d6ZET<br \/>\n<\/strong> Helicobacter pylori, gastrit, duodenal ve peptik \u00fclser, gastrik karsinoma ve mukoza ile ili\u015fkili lenfoid doku lenfomas\u0131 gibi pek \u00e7ok gastrointestinal sistemle ilgili hastal\u0131klara neden olmaktad\u0131r. G\u00fcn\u00fcm\u00fczde H. pylori\u2019nin eradike edilmesi i\u00e7in \u00e7e\u015fitli \u00e7oklu antibiyotik rejimleri kullan\u0131lmakta, ancak gerek antibiyotik kullan\u0131m\u0131nda yan etkilerin g\u00f6zlenmesi, gerek bakterilerin antibiyotiklere diren\u00e7 geli\u015ftirmeleri ve gerekse istenilen yan\u0131t\u0131n her vakada al\u0131namamas\u0131 yeni tedavi aray\u0131\u015flar\u0131n\u0131n ortaya \u00e7\u0131kmas\u0131na ve b\u00f6ylece do\u011fal kaynaklara y\u00f6nelimin h\u0131zlanmas\u0131na neden olmu\u015ftur.Propolis, bal ar\u0131lar\u0131 taraf\u0131ndan bitkilerden toplanan do\u011fal bir \u00fcr\u00fcn olup, antimikrobiyal, antioksidan, antit\u00fcm\u00f6ral, antiinflamatuar gibi biyolojik aktivitelere sahip oldu\u011fu bilimsel \u00e7al\u0131\u015fmalarla g\u00f6sterilmi\u015ftir. Bu \u00e7al\u0131\u015fmada, Kayseri ve \u00e7evresinden toplanan propolisin H. pylori \u00fczerine antimikrobiyal aktivitesinin in vitro olarak ara\u015ft\u0131r\u0131lmas\u0131 ama\u00e7lanm\u0131\u015ft\u0131r.\u00c7al\u0131\u015fmada, propolisin etanol ile haz\u0131rlanan ektresi kullan\u0131ld\u0131. Propolisin etanolik ekstrakt\u0131n\u0131n 16-1024 \u00b5g\/ml aral\u0131\u011f\u0131nda iki kat artan konsantrasyonlar\u0131 haz\u0131rland\u0131 ve H. pylori \u00fczerine antimikrobiyal aktivitesi disk dif\u00fczyon ve agar dil\u00fcsyon y\u00f6ntemleri kullan\u0131larak ara\u015ft\u0131r\u0131ld\u0131. Disk dif\u00fczyon testine g\u00f6re 64 \u00b5g\/ml ve \u00fczeri konsantrasyonlarda belirgin inhibisyon zon \u00e7aplar\u0131 g\u00f6zlenirken, agar dil\u00fcsyon y\u00f6nteminde minimal inhibit\u00f6r konsantrasyon 128 \u00b5g\/ml olarak belirlendi.Sonu\u00e7 olarak Kayseri ve \u00e7evresinden toplanan propolisin H. pylori\u2019ye etkili oldu\u011fu g\u00f6sterilmi\u015f olup, bu \u00e7al\u0131\u015fman\u0131n propolisin H. pylori eradikasyonunda kullan\u0131m\u0131 ile ilgili deneysel ve klinik \u00e7al\u0131\u015fmalar\u0131n \u00f6n\u00fcn\u00fc a\u00e7aca\u011f\u0131 d\u00fc\u015f\u00fcn\u00fclm\u00fc\u015ft\u00fcr.<br \/>\n<strong>Anahtar Kelimeler: <\/strong> Helicobacter pylori; antimikrobiyal aktivite; propolis<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ersin Karabulut Y\u00fcksek Lisans Tezi, Erciyes \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Farmas\u00f6tik Mikrobiyoloji Anabilim Dal\u0131, 2011, 62 s. TEZ NO: 311436<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[37],"tags":[],"class_list":["post-17943","post","type-post","status-publish","format-standard","","category-yuksek-lisans-tezleri","yazarlar-ersin-karabulut","anahtarkelimeler-antimikrobiyal-etki","anahtarkelimeler-apiterapi","anahtarkelimeler-helicobacter-pylori","anahtarkelimeler-propolis","anahtarkelimeler-propolisin-faydalari"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17943","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17943"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17943\/revisions"}],"predecessor-version":[{"id":17944,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17943\/revisions\/17944"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17943"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17943"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17943"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}