{"id":17919,"date":"2015-04-06T23:17:35","date_gmt":"2015-04-06T20:17:35","guid":{"rendered":"http:\/\/balarisi.org\/?p=17919"},"modified":"2015-04-08T11:25:05","modified_gmt":"2015-04-08T08:25:05","slug":"nitrik-oksit-sentaz-inhibisyonu-olusturulan-sicanlarda-kan-basinci-tirozin-hidroksilaz-aktivitesi-ile-birlikte-bazi-biyokimyasal-ve-hematolojik-parametreler-uzerine-propolisin-etkileri","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17919","title":{"rendered":"Nitrik oksit sentaz inhibisyonu olu\u015fturulan s\u0131\u00e7anlarda kan bas\u0131nc\u0131, tirozin hidroksilaz aktivitesi ile birlikte baz\u0131 biyokimyasal ve hematolojik parametreler \u00fczerine propolisin etkileri"},"content":{"rendered":"<p><strong>Ay\u015fe G\u00f6\u011febakan<\/strong><br \/>\nY\u00fcksek Lisans Tezi, Ni\u011fde \u00dcniversitesi \/ Fen Bilimleri Enstit\u00fcs\u00fc \/ Biyoloji Anabilim Dal\u0131, 2010, 77 s.<br \/>\nTEZ NO: <strong>271434<\/strong><br \/>\n<!--more--><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"https:\/\/tez.yok.gov.tr\/UlusalTezMerkezi\/tarama.jsp\" target=\"_blank\">Sorgu Penceresine TEZ NO\u2019yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n<p><strong>\u00d6ZET<br \/>\n<\/strong> Nitrik oksit (NO) sentezinin ve biyoyararlan\u0131m\u0131n\u0131n azalmas\u0131 hipertansiyon (HT) geli\u015fiminde \u00f6nemli rol oynar. Propolis bal ar\u0131lar\u0131 taraf\u0131ndan \u00e7e\u015fitli bitkilerden toplanan re\u00e7inemsi bir \u00fcr\u00fcnd\u00fcr. Tirozin hidroksilaz (TH) katekolaminlerin biyosentezinde h\u0131z k\u0131s\u0131tlay\u0131c\u0131 enzimdir. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131; kronik NG-nitro-L-arjinin metil ester (L-NAME) uygulamas\u0131 ile nitrik oksit sentaz (NOS) inhibisyonu yap\u0131lan s\u0131\u00e7anlarda kan bas\u0131nc\u0131, adrenal medulla, kalp ve hipotalamus dokular\u0131nda TH aktivitesi ve total RNA \u00fczerine propolisin etkilerini ara\u015ft\u0131rmakt\u0131r. Deney hayvanlar\u0131 kontrol, L-NAME (15 g\u00fcn, 40mg\/kg, intraperitonal), propolis (15 g\u00fcn, 200 mg\/kg, gavaj yoluyla) ve L-NAME+propolis (L-NAME uygulamas\u0131n\u0131n son 5 g\u00fcn\u00fc 200 mg\/kg, gavaj yoluyla) olmak \u00fczere d\u00f6rt gruba ayr\u0131ld\u0131. L-NAME uygulanan gruplarda, TH aktivitesi ve total RNA seviyeleri adrenal medulla, kalp ve hipotalamus dokular\u0131nda anlaml\u0131 art\u0131\u015f g\u00f6sterdi (p&lt;0.05). L-NAME grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda L-NAME+propolis grubunda TH aktivitesi ve total RNA seviyelerinde anlaml\u0131 d\u00fc\u015f\u00fc\u015fler g\u00f6zlendi (p&lt;0.05). Propolis uygulanan s\u0131\u00e7anlar\u0131n TH aktiviteleri kontrol grubuna g\u00f6re artt\u0131. L-NAME, kontrol grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda kan bas\u0131nc\u0131nda anlaml\u0131 art\u0131\u015fa neden oldu (p&lt;0.05). L-NAME uygulanan s\u0131\u00e7anlara propolis uygulamas\u0131 ile kan bas\u0131nc\u0131 azald\u0131; fakat bu azalma istatistiksel olarak anlaml\u0131 de\u011fildi (p&gt;0.05).L-NAME uygulamas\u0131 glukoz, albumin, globulin, kreatinin, \u00fcre, trigliserit, kolesterol, AST, ALT, ALP, GGT, RBC, WBC, HB, HCT, n\u00f6trofil, eozinofil, bazofil ve monosit de\u011ferlerinde art\u0131\u015fa; fakat toplam protein, PLT ve lenfosit de\u011ferlerinde anlaml\u0131 azalmaya neden oldu (p&lt;0.05). L-NAME uygulanan grup ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, L-NAME+propolis grubunda bu de\u011ferlerde anlaml\u0131 de\u011fi\u015fikliklerin oldu\u011fu g\u00f6zlendi (p&lt;0.05). Propolis uygulanan grupta ise bu de\u011ferlerde herhangi bir de\u011fi\u015fiklik tespit edilmedi (p&gt;0.05).Bu sonu\u00e7lar, propolisin TH aktivitesini azaltt\u0131\u011f\u0131n\u0131, katekolaminlerin sentezini ve kan bas\u0131nc\u0131n\u0131 d\u00fczenleyebildi\u011fini g\u00f6stermektedir.<br \/>\n<strong>Anahtar Kelimeler: <\/strong>Hipertansiyon, L-NAME, Propolis, Adrenal medulla, Kalp, Hipotalamus, Nitrik oksit, Biyokimyasal parametreler, Hematolojik parametreler<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ay\u015fe G\u00f6\u011febakan Y\u00fcksek Lisans Tezi, Ni\u011fde \u00dcniversitesi \/ Fen Bilimleri Enstit\u00fcs\u00fc \/ Biyoloji Anabilim Dal\u0131, 2010, 77 s. TEZ NO: 271434<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[37],"tags":[],"class_list":["post-17919","post","type-post","status-publish","format-standard","","category-yuksek-lisans-tezleri","yazarlar-ayse-gogebakan","anahtarkelimeler-propolis","anahtarkelimeler-propolis-ve-kan-basinci","anahtarkelimeler-propolisin-faydalari"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17919"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17919\/revisions"}],"predecessor-version":[{"id":17920,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17919\/revisions\/17920"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}