{"id":17911,"date":"2015-04-06T23:15:15","date_gmt":"2015-04-06T20:15:15","guid":{"rendered":"http:\/\/balarisi.org\/?p=17911"},"modified":"2015-04-09T11:55:05","modified_gmt":"2015-04-09T08:55:05","slug":"karbontetraklorur-ile-olusturulan-karaciger-intoksikasyonunda-royal-jellynin-antioksidan-enzimler-ve-mineral-madde-duzeyleri-uzerine-etkisi","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17911","title":{"rendered":"Karbontetraklor\u00fcr ile olu\u015fturulan karaci\u011fer intoksikasyonunda Royal Jelly\u2019nin antioksidan enzimler ve mineral madde d\u00fczeyleri \u00fczerine etkisi"},"content":{"rendered":"<p><strong>Fatma Y\u0131lmaz<\/strong><br \/>\nY\u00fcksek Lisans Tezi, Afyon Kocatepe \u00dcniversitesi \/ Fen Bilimleri Enstit\u00fcs\u00fc \/ Kimya Anabilim Dal\u0131, 2010, 93 s.<br \/>\nTEZ NO: <strong>259461<\/strong><br \/>\n<!--more--><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"https:\/\/tez.yok.gov.tr\/UlusalTezMerkezi\/tarama.jsp\" target=\"_blank\">Sorgu Penceresine TEZ NO\u2019yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n<p><strong>\u00d6ZET<br \/>\n<\/strong> In vivo deneysel \u00e7al\u0131\u015fmada ratlar, her grupta sekiz adet olmak \u00fczere alt\u0131 gruba ayr\u0131ld\u0131. Sham ve 100 mg\/kg RJ grubu hari\u00e7 t\u00fcm gruplara yirmi g\u00fcn boyunca g\u00fcn a\u015f\u0131r\u0131, 0.4 mL\/kg CCl4 + 0.4 mL\/kg ay\u00e7i\u00e7ek ya\u011f\u0131 verilerek intoksikasyon olu\u015fturuldu. \u0130ntoksikasyon olu\u015fturulan gruplardan CCl4 grubuna herhangi bir tedavi verilmezken, di\u011fer \u00fc\u00e7 tedavi grubuna s\u0131ras\u0131yla 50, 100, 200 mg\/kg RJ verildi. \u00c7al\u0131\u015fma sonunda, eritrositte s\u00fcperoksid dismutaz (SOD), glutatyon peroksidaz (GPx), katalaz (CAT) ve serumda biyoelement d\u00fczeyleri analiz edildi. Elde edilen sonu\u00e7lara g\u00f6re CCl4 intoksikasyonu SOD (p&lt;0.001), GPx (p&lt;0.001) ve CAT (p&lt;0.01) aktivitelerinde azalmaya sebep olurken, RJ ile tedavi edilen gruplarda bu antioksidan enzim aktivitelerinde art\u0131\u015f g\u00f6r\u00fcld\u00fc. CCl4 serum mineral madde d\u00fczeyleri \u00fczerinde de de\u011fi\u015fikliklere sebep oldu. Zn ve K d\u00fczeylerinde toksikasyon grubunda sham grubuna g\u00f6re, ayr\u0131ca yine K d\u00fczeyinde tedavi gruplar\u0131nda sham ve 100 mg\/kg RJ gruplar\u0131na g\u00f6re art\u0131\u015f g\u00f6r\u00fcld\u00fc (p&lt;0.001). Be ve Ga d\u00fczeylerinde CCl4 + 100 mg\/kg RJ grubunda toksikasyon, sham ve 100 mg\/kg RJ gruplar\u0131na g\u00f6re artma g\u00f6r\u00fcld\u00fc (p&lt;0.001). Ca ve Sr d\u00fczeylerinde CCl4 + 100 mg\/kg RJ hari\u00e7 tedavi gruplar\u0131nda toksikasyon grubuna g\u00f6re azalma g\u00f6r\u00fcld\u00fc. Sonu\u00e7 olarak; CCl4 intoksikasyonu antioksidan enzim d\u00fczeylerinde azalmalara sebep olmu\u015f ve RJ terapisi antioksidan enzim aktivitesini artt\u0131rm\u0131\u015ft\u0131r. Ayr\u0131ca RJ bozulan pek\u00e7ok mineral d\u00fczeylerini de normale yakla\u015ft\u0131rm\u0131\u015ft\u0131r. RJ\u2019nin bu \u00f6zelliklerinden dolay\u0131 karaci\u011fer hastal\u0131klar\u0131n\u0131n tedavisinde faydal\u0131 olabilece\u011fi d\u00fc\u015f\u00fcn\u00fclmektedir.<br \/>\n<strong>Anahtar Kelimeler: <\/strong> Antioksidan enzim; Biyoelement; CCl4 intoksikasyonu; Royal jelly<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fatma Y\u0131lmaz Y\u00fcksek Lisans Tezi, Afyon Kocatepe \u00dcniversitesi \/ Fen Bilimleri Enstit\u00fcs\u00fc \/ Kimya Anabilim Dal\u0131, 2010, 93 s. TEZ NO: 259461<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[37],"tags":[],"class_list":["post-17911","post","type-post","status-publish","format-standard","","category-yuksek-lisans-tezleri","yazarlar-fatma-yilmaz","anahtarkelimeler-apiterapi","anahtarkelimeler-ari-sutu","anahtarkelimeler-ari-sutunun-faydalari","anahtarkelimeler-karaciger-hasari"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17911","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17911"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17911\/revisions"}],"predecessor-version":[{"id":17912,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17911\/revisions\/17912"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17911"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17911"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17911"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}