{"id":17907,"date":"2015-04-06T23:13:59","date_gmt":"2015-04-06T20:13:59","guid":{"rendered":"http:\/\/balarisi.org\/?p=17907"},"modified":"2015-04-09T11:55:52","modified_gmt":"2015-04-09T08:55:52","slug":"farkli-duzeylerde-propolis-uygulamalarinin-farelerde-lipid-peroksidasyonu-mda-ile-bazi-biyokimyasal-parametrelere-etkilerinin-degerlendirilmesi","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17907","title":{"rendered":"Farkl\u0131 d\u00fczeylerde propolis uygulamalar\u0131n\u0131n farelerde lipid peroksidasyonu (MDA) ile baz\u0131 biyokimyasal parametrelere etkilerinin de\u011ferlendirilmesi"},"content":{"rendered":"<p><strong>Ahu Fatma Bozkurt<\/strong><br \/>\nY\u00fcksek Lisans Tezi, Sel\u00e7uk \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Biyokimya (Veterinerlik) Anabilim Dal\u0131, 2010, 56 s.<br \/>\nTEZ NO: <strong>260684<\/strong><br \/>\n<!--more--><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"https:\/\/tez.yok.gov.tr\/UlusalTezMerkezi\/tarama.jsp\" target=\"_blank\">Sorgu Penceresine TEZ NO\u2019yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n<p><strong>\u00d6ZET<br \/>\n<\/strong> Bu \u00e7al\u0131\u015fmada i\u00e7me sular\u0131na farkl\u0131 oranlarda (0, 10, 20, 30 mg\/kgCA\/g\u00fcn) propolis kat\u0131lan erkek farelerde lipid peroksidasyonu (MDA) de\u011fi\u015fiklikleri ile baz\u0131 metabolik, enzimatik ve lipid de\u011ferlerinde ortaya \u00e7\u0131kan de\u011fi\u015fimler incelenmi\u015ftir.Ara\u015ft\u0131rmada 3 ayl\u0131k ya\u015fta, canl\u0131 a\u011f\u0131rl\u0131klar\u0131 birbirine yak\u0131n, toplam 128 adet beyaz erkek fare kullan\u0131ld\u0131. Bu hayvanlar herbirinde 32 adet fare i\u00e7eren 4 gruba ayr\u0131ld\u0131. Sel\u00e7uk \u00dcniversitesi Veteriner Fak\u00fcltesi Deney Hayvanlar\u0131 \u00dcnitesi\u2019nde y\u00fcr\u00fct\u00fclen ara\u015ft\u0131rma 60 g\u00fcn s\u00fcrd\u00fcr\u00fcld\u00fc. \u00c7al\u0131\u015fmada kontrol ile 10 mg Propolis \/ kg canl\u0131 a\u011f\/g\u00fcn; 20 mg Propolis \/ kg canl\u0131 a\u011f\/g\u00fcn ve 30 mg Propolis \/ kg canl\u0131 a\u011f\/g\u00fcn; olmak \u00fczere toplam 4 deneme grubu olu\u015fturuldu. Deneme ba\u015f\u0131nda ve sonunda olmak \u00fczere iki periyot halinde (1. g\u00fcn ve 60. g\u00fcn) al\u0131nan kan \u00f6rneklerinde, spektrofotometrik olarak MDA ile baz\u0131 metabolik (Toplam protein, albumin, Ca, glikoz) enzimatik (AST, ALT, LDH) ve lipid (total kolesterol, HDL-LDL kolesterol, trigliserit, fosfolipid) de\u011ferlerinin \u00f6l\u00e7\u00fcmleri ger\u00e7ekle\u015ftirildi.Malondialdehit (MDA), 3. ve 4. gruplarda \u00f6nemli oranda d\u00fc\u015f\u00fc\u015f g\u00f6stermi\u015ftir. Albumin verilerinin 2. grup d\u0131\u015f\u0131ndaki gruplarda 1. g\u00fcne oranla 60 g\u00fcnde \u00f6nemli art\u0131\u015flar i\u00e7erisinde oldu\u011fu g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Kalsiyum (Ca) de\u011ferlerinde gruplar aras\u0131nda belirgin bir de\u011fi\u015fim g\u00f6zlenmez iken glikoz de\u011ferlerinde hem her bir grubun 1. g\u00fcn ve 60. g\u00fcn de\u011ferlerinde hem de 4. grupta belirgin ve anlaml\u0131 (P&lt;0.012) olmak \u00fczere t\u00fcm gruplarda d\u00fc\u015f\u00fc\u015f g\u00f6sterdi\u011fi g\u00f6zlenmektedir.AST de\u011ferlerinin her bir grupta 1. g\u00fcne g\u00f6re 60 g\u00fcnde anlaml\u0131 y\u00fckselmeler g\u00f6sterirken; 4. grupta bu y\u00fckselmenin daha belirgin (P&lt;0.000) oldu\u011fu saptanm\u0131\u015ft\u0131r. ALT de\u011ferlerinde ise sadece 4. grupta belirgin olan de\u011fi\u015fim, AST de\u011ferlerinin aksine, d\u00fc\u015f\u00fc\u015f \u015feklinde ger\u00e7ekle\u015fmi\u015ftir.Lipid parametreleri y\u00f6n\u00fcnden yap\u0131lan incelemede ise trigliserit ve toplam kolesterol de\u011ferlerinin her ikisi de gruplar da azalma e\u011filimi g\u00f6stermi\u015f, ancak bu d\u00fc\u015f\u00fc\u015f 4. grupta belirgin ve istatistiki olarak anlaml\u0131 (P&lt;0.001) bulunmu\u015ftur. HDL de\u011ferlerinin 2. gruptan itibaren anlaml\u0131 \u015fekilde y\u00fckseldi\u011fi; LDL de\u011ferlerinin ise sadece 4. grupta anlaml\u0131 (P&lt;0.000) olarak d\u00fc\u015f\u00fc\u015f g\u00f6sterdi\u011fi, di\u011fer gruplarda spesifik olmayan de\u011fi\u015fimler i\u00e7erisinde oldu\u011fu belirlenmi\u015ftir. Fosfolipid de\u011ferlerinde ise 3. (P&lt;0.024) ve 4. (P&lt;0.000) gruplarda belirgin bir y\u00fckselme ortaya \u00e7\u0131km\u0131\u015ft\u0131r.Sonu\u00e7 olarak; farelerde i\u00e7me suyu ile uygulanan propolisin lipid peroksidasyon g\u00f6stergesi olan MDA de\u011ferlerini 20 ve 30 mg propolis gruplar\u0131nda \u00f6nemli olmak \u00fczere d\u00fc\u015f\u00fcrd\u00fc\u011f\u00fc, metabolik, enzimatik ve lipid de\u011ferlerinde de genel olarak canl\u0131 organizma lehine olabilecek de\u011fi\u015fimler sa\u011flad\u0131\u011f\u0131 belirlenmi\u015ftir. Farelerde y\u00fcr\u00fct\u00fclen bu \u00e7al\u0131\u015fma ile elde edilen verilerin de\u011fi\u015fik t\u00fcrden canl\u0131 organizmalar\u0131n beslenmesinde ve bu konuda yap\u0131lacak farkl\u0131 \u00e7al\u0131\u015fmalar\u0131n de\u011ferlendirilmesinde yararl\u0131 olaca\u011f\u0131 kan\u0131s\u0131na var\u0131lm\u0131\u015ft\u0131r.<br \/>\n<strong>Anahtar Kelimeler: <\/strong> Fare; MDA; biyokimyasal de\u011ferler.; propolis<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ahu Fatma Bozkurt Y\u00fcksek Lisans Tezi, Sel\u00e7uk \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Biyokimya (Veterinerlik) Anabilim Dal\u0131, 2010, 56 s. TEZ NO: 260684<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[37],"tags":[],"class_list":["post-17907","post","type-post","status-publish","format-standard","","category-yuksek-lisans-tezleri","yazarlar-ahu-fatma-bozkurt","anahtarkelimeler-propolis","anahtarkelimeler-propolis-ve-hayvan-besleme"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17907","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17907"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17907\/revisions"}],"predecessor-version":[{"id":17908,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17907\/revisions\/17908"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17907"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17907"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17907"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}