{"id":17854,"date":"2015-04-06T11:00:47","date_gmt":"2015-04-06T08:00:47","guid":{"rendered":"http:\/\/balarisi.org\/?p=17854"},"modified":"2015-04-09T12:12:26","modified_gmt":"2015-04-09T09:12:26","slug":"leishmania-tropica-uzerine-kayseri-propolisinin-antileishmanial-aktivitesinin-arastirilmasi","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17854","title":{"rendered":"Leishmania tropica \u00fczerine Kayseri propolisinin antileishmanial aktivitesinin ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p><strong>Song\u00fcl Albayrak<\/strong><br \/>\nY\u00fcksek Lisans Tezi, Erciyes \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Farmas\u00f6tik Mikrobiyoloji Anabilim Dal\u0131, 2009, 58 s.<br \/>\nTEZ NO: <strong>242503<\/strong><br \/>\n<!--more--><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"https:\/\/tez.yok.gov.tr\/UlusalTezMerkezi\/tarama.jsp\" target=\"_blank\">Sorgu Penceresine TEZ NO&#8217;yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n<p><strong>\u00d6ZET<br \/>\n<\/strong> Leishmania, Kinetoplasteae s\u0131n\u0131f\u0131nda ve Trypanosomatida ailesinde yer alan intrasell\u00fcler ya\u015fayan doku parazitidir. Kutan\u00f6z leishmaniasis \u00fclkemizde G\u00fcneydo\u011fu Anadolu B\u00f6lgesi\u2019 nde endemiktir ve genellikle etken olarak Leishmania tropica izole edilmektedir.Propolis, bal ar\u0131lar\u0131 taraf\u0131ndan bitkilerden toplanan ve mumla kar\u0131\u015ft\u0131r\u0131larak kovan i\u00e7erisinde bir\u00e7ok amaca y\u00f6nelik olarak kullan\u0131lan do\u011fal bir \u00fcr\u00fcnd\u00fcr. Son zamanlarda propolisin \u00e7e\u015fitli biyolojik aktiviteleri ara\u015ft\u0131rmac\u0131lar\u0131n yo\u011fun ilgisini \u00e7ekmektedir. Leishmaniasis tedavisinde rutin olarak kullan\u0131lan antimon bile\u015fiklerinin yan etkilerinin fazla olmas\u0131 nedeniyle bu hastal\u0131\u011f\u0131n tedavisi i\u00e7in alternatif tedavi ara\u015ft\u0131rmalar\u0131 devam etmektedir. Literat\u00fcrde propolisin Leishmania paraziti \u00fczerine etkisini g\u00f6steren s\u0131n\u0131rl\u0131 say\u0131da \u00e7al\u0131\u015fmaya rastland\u0131. Bu \u00e7al\u0131\u015fmada, propolisin Leishmania tropica parazitine kar\u015f\u0131 antileishmanial etkinli\u011fi de\u011ferlendirildi ve leishmaniasis tedavisinde kullan\u0131lan sodyum stiboglukonat\u0131n etkisi ile propolisin etkisi kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131. Kayseri\u2019 den toplanan propolisin Leishmania tropica paraziti \u00fczerine etkisi mikroskobik g\u00f6zlem, mikrobroth dil\u00fcsyon y\u00f6ntem ve t\u00fcrbidometrik y\u00f6ntem ile incelendi. Mikroskobik g\u00f6zlem ve mikrobroth dil\u00fcsyon y\u00f6ntemi ile propolisin 32 \u00b5g\/ ml konsantrasyonundan itibaren Leishmania tropica\u2019 y\u0131 inhibe etti\u011fi g\u00f6zlendi. Ayr\u0131ca, propolis konsantrasyonu ve ink\u00fcbasyon s\u00fcresi artt\u0131k\u00e7a propolisin antileishmanial etkisinin artt\u0131\u011f\u0131 belirlendi. Sodyum stiboglukonat ile propolis etkinli\u011fi kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, propolisin d\u00fc\u015f\u00fck konsantrasyonlarda bile etkili oldu\u011fu tespit edildi.Sonu\u00e7 olarak, yan etkisi olmayan do\u011fal bir \u00fcr\u00fcn olan Kayseri propolisinin \u00e7ok k\u00fc\u00e7\u00fck konsantrasyonlarda bile Leishmania tropica\u2019 ya kar\u015f\u0131 etkili oldu\u011fu belirlendi.<br \/>\n<strong>Anahtar Kelimeler: <\/strong> Kayseri; Leishmania tropica; Propolis; Sodyum stiboglukonat<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Song\u00fcl Albayrak Y\u00fcksek Lisans Tezi, Erciyes \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Farmas\u00f6tik Mikrobiyoloji Anabilim Dal\u0131, 2009, 58 s. TEZ NO: 242503<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[37],"tags":[],"class_list":["post-17854","post","type-post","status-publish","format-standard","","category-yuksek-lisans-tezleri","yazarlar-songul-albayrak","anahtarkelimeler-apiterapi","anahtarkelimeler-kayseri","anahtarkelimeler-propolis","anahtarkelimeler-propolisin-faydalari"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17854","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17854"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17854\/revisions"}],"predecessor-version":[{"id":17855,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17854\/revisions\/17855"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17854"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17854"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17854"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}