{"id":17786,"date":"2015-04-02T17:41:06","date_gmt":"2015-04-02T14:41:06","guid":{"rendered":"http:\/\/balarisi.org\/?p=17786"},"modified":"2015-04-09T14:52:11","modified_gmt":"2015-04-09T11:52:11","slug":"ogrenme-ve-hafizanin-sekillendigi-beyin-bolgelerinde-alkolun-olusturdugu-hasarlarda-propolisin-etkileri","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17786","title":{"rendered":"\u00d6\u011frenme ve haf\u0131zan\u0131n \u015fekillendi\u011fi beyin b\u00f6lgelerinde alkol\u00fcn olu\u015fturdu\u011fu hasarlarda propolisin etkileri"},"content":{"rendered":"<p><strong>Z\u00fcmr\u00fct Y\u0131lmaz<\/strong><br \/>\nY\u00fcksek Lisans Tezi, \u0130n\u00f6n\u00fc \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Fizyoloji Anabilim Dal\u0131, 2006, 68 s.<br \/>\nTEZ NO: <strong>192985<\/strong><br \/>\n<!--more--><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"https:\/\/tez.yok.gov.tr\/UlusalTezMerkezi\/tarama.jsp\" target=\"_blank\">Sorgu Penceresine TEZ NO\u2019yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n<p><strong>\u00d6ZET<br \/>\n<\/strong>Alkol\u00fcn metabolizasyonu sonucunda a\u00e7\u0131\u011fa \u00e7\u0131kan asetaldehit ve serbest radikallerdenkaynaklanan oksidatif stres, beyinde \u00f6\u011frenme merkezlerinde oksidatif hasara nedenolarak \u00f6\u011frenme ve belle\u011fi bask\u0131lar. Propolis, i\u00e7erdi\u011fi flavonoidlerden dolay\u0131 kuvvetliantioksidan \u00f6zellik g\u00f6stermektedir. \u00c7al\u0131\u015fmam\u0131zda; alkol\u00fcn \u00f6\u011frenme merkezlerindeolu\u015fturdu\u011fu hasarlara kar\u015f\u0131 propolisin olas\u0131 koruyucu rol\u00fcn\u00fc ara\u015ft\u0131rmay\u0131 ama\u00e7lad\u0131k.Gen\u00e7- eri\u015fkin Wistar-Albino s\u0131\u00e7anlar 4 gruba ayr\u0131ld\u0131 (n=8). Alkol gruplar\u0131 30 g\u00fcnboyunca kademeli olarak artan konsantrasyonlarda (%2,4 &#8211; %7,2 V \/ V) alkoll\u00fc s\u0131v\u0131i\u00e7ecek diyeti ile beslendi. Propolis gruplar\u0131na 150 mg\/kg propolis \u00e7\u00f6zeltisi eklendi.Kontrol grubuna ise alkol\u00fcn kalorisine e\u015fde\u011fer alkol i\u00e7ermeyen s\u0131v\u0131 i\u00e7ecek diyetiuyguland\u0131. Deney s\u00fcresince deneklerin g\u00fcnl\u00fck ald\u0131klar\u0131 besin miktarlar\u0131 ve kilode\u011fi\u015fimleri kay\u0131t edildi.K\u0131sa s\u00fcreli bellek ve \u00f6\u011frenmenin test edilebilmesi i\u00e7in deney \u00f6ncesinde, deneysonras\u0131nda ve alkol konsantrasyonunun art\u0131r\u0131ld\u0131\u011f\u0131 g\u00fcnlerden \u00f6nce T-labirent testiuyguland\u0131. Deney sonunda sakrifikiye edilen s\u0131\u00e7anlar\u0131n beyinlerinin serebellum,hipokampus, serebral korteks b\u00f6lgelerinde, antioksidan enzimlerden SOD, CAT, GSH-Pxaktiviteleri ile TBARS ve Nitrat \/Nitrit d\u00fczeyleri kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131.Gruplar\u0131n T-labirentteki de\u011ferleri bazal s\u00fcre, sak\u0131nma 1 ve sak\u0131nma 2 s\u00fcreleri a\u00e7\u0131s\u0131ndankar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda; kontrol grubu ile propolis grubu aras\u0131nda fark g\u00f6r\u00fclmezken (P&gt;0,05),alkol grubunun T-labirent de\u011ferlerinin kontrol ve propolis grubuna k\u0131yasla azald\u0131\u011f\u0131 fakatbu azalman\u0131n sadece 11. g\u00fcnde yap\u0131lan testlerde istatistiksel olarak anlaml\u0131 oldu\u011fu(P&lt;0,05), Propolis + alkol grubu de\u011ferleri alkol grubundan y\u00fcksek, kontrol ve propolisgruplar\u0131ndan d\u00fc\u015f\u00fck \u00e7\u0131km\u0131\u015f olmakla birlikte sadece 11. ve 30. g\u00fcnlerde al\u0131nan kay\u0131tlar istatistiksel olarak anlaml\u0131 bulundu (P&lt;0,05).Propolis grubunun hipokampus ve korteks dokusundaki SOD ve GSH-Px enzimaktiviteleri kontrol gurubuna g\u00f6re anlaml\u0131 d\u00fczeyde art\u0131\u015f g\u00f6sterdi (P&lt;0,05). Bu daporpolisin antioksidan \u00f6zelligi oldu\u011funun bir g\u00f6stergesi olarak kullan\u0131labilir.Hipokampus, serebral korteks ve serebellum dokular\u0131ndaki SOD, GSH-Px enzimaktiviteleri gruplar aras\u0131nda kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda; alkol grubu enzim aktivitesinin kontrolve propolis grubundaki enzim aktivitelerinden daha az oldu\u011fu, propolis + alkolgrubundaki enzim aktivitesinin ise alkol grubuna oranla artt\u0131\u011f\u0131 g\u00f6zlenmi\u015ftir. Fakatbunlarda sadce hipokampus ve serebral korteks dokusundaki enzim de\u011fi\u015fmeleriistatistiksel olarak anlaml\u0131 iken serebellum dokusundaki enzim de\u011fi\u015fimleri istatistikselolarak anlaml\u0131 bulunamam\u0131\u015ft\u0131r.Sonu\u00e7 olarak; propolisin kuvvetli bir anti oksidan \u00f6zelli\u011fe sahip oldu\u011fu, alkol\u00fcn artankonsantrasyonlarda oksidatif strese ba\u011fl\u0131 olarak beyinde \u00f6\u011frenme merkezlerindehasarlara neden oldu\u011fu, propolisin i\u00e7erdi\u011fi antioksidan \u00f6zellikten dolay\u0131 alkol\u00fcnolu\u015fturdu\u011fu hasarlar\u0131 tersine \u00e7evirici etkiye sahip oldu\u011fu sonucuna var\u0131ld\u0131.<br \/>\n<strong>Anahtar Kelimeler: <\/strong>Alkol, Hipokampus, Propolis, T-labirent, Antioksidan Enzimler.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Z\u00fcmr\u00fct Y\u0131lmaz Y\u00fcksek Lisans Tezi, \u0130n\u00f6n\u00fc \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Fizyoloji Anabilim Dal\u0131, 2006, 68 s. TEZ NO: 192985<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[37],"tags":[],"class_list":["post-17786","post","type-post","status-publish","format-standard","","category-yuksek-lisans-tezleri","yazarlar-zumrut-yilmaz","anahtarkelimeler-antioksidan-etki","anahtarkelimeler-apiterapi","anahtarkelimeler-propolis","anahtarkelimeler-propolisin-faydalari"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17786","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17786"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17786\/revisions"}],"predecessor-version":[{"id":17787,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17786\/revisions\/17787"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17786"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17786"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17786"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}