{"id":17591,"date":"2014-10-22T23:24:14","date_gmt":"2014-10-22T20:24:14","guid":{"rendered":"http:\/\/balarisi.org\/?p=17591"},"modified":"2015-03-30T22:02:27","modified_gmt":"2015-03-30T19:02:27","slug":"endotoksemi-olusturulmus-sicanlarda-propolisin-karaciger-koruyucu-etkinliginin-arastirilmasi","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17591","title":{"rendered":"Endotoksemi olu\u015fturulmu\u015f s\u0131\u00e7anlarda propolisin karaci\u011fer koruyucu etkinli\u011finin ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p><strong>Z\u00fcleyha Do\u011fanyi\u011fit<\/strong><br \/>\nDoktora Tezi, Erciyes \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Histoloji ve Embriyoloji Anabilim Dal\u0131, 2012, 104s.<br \/>\nTEZ NO: 311320<br \/>\n<!--more--><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"https:\/\/tez.yok.gov.tr\/UlusalTezMerkezi\/tarama.jsp\" target=\"_blank\">Sorgu Penceresine TEZ NO&#8217;yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n<p><strong>\u00d6ZET<br \/>\n<\/strong>Endotoksik \u015fok hipotansiyon, zay\u0131f doku perf\u00fczyonu ve \u00e7oklu organ yetmezli\u011fi ile karakterize edilen ve yatan hastalarda \u00f6l\u00fcme neden olan etkenlerin ba\u015f\u0131nda gelen ciddi bir komplikasyondur. Ba\u015fta lipopolisakkarit (LPS) olmak \u00fczere endotoksinler taraf\u0131ndan olu\u015fturulan endotokseminin patofizyolojik mekanizmalar\u0131n\u0131n anla\u015f\u0131lmas\u0131nda ve tedavisinde pek \u00e7ok strateji geli\u015ftirilmesine ra\u011fmen, hala yo\u011fun bak\u0131m \u00fcnitelerinin b\u00fcy\u00fck bir problemidir. Bu ara\u015ft\u0131rma da son y\u0131llarda antibakteriyel, antioksidan, antiinflamatuvar ve antit\u00fcmoral etkinliklerine dair \u00e7ok say\u0131da ara\u015ft\u0131rmaya konu olan propolisin s\u0131\u00e7anlarda olu\u015fturulacak deneysel endotoksemideki karaci\u011feri koruyucu etkinli\u011fini belirlemek ama\u00e7lanm\u0131\u015ft\u0131r.\u000b\u00c7al\u0131\u015fmada, Sprague dawley t\u00fcr\u00fc (200-300gr a\u011f\u0131rl\u0131\u011f\u0131nda) di\u015fi s\u0131\u00e7anlar kullan\u0131lm\u0131\u015ft\u0131r. Her birinde on tane olmak \u00fczere s\u0131\u00e7anlar yedi gruba ayr\u0131lm\u0131\u015ft\u0131r. Kontrol grubunun d\u0131\u015f\u0131ndaki gruplar da LPS&#8217;nin dozuna ve propolisin \u00f6nce ve sonra verilmesine g\u00f6re d\u00fczenlenmi\u015ftir.\u000bAl\u0131nan dokularda yap\u0131lan histolojik de\u011ferlendirmeler sonucunda LPS uygulanan gruplarda kontrol grubuna g\u00f6re vask\u00fcler konjesyon, n\u00f6trofil infiltrasyonu, Kuppfer h\u00fccre aktivasyonu ve nekroz olmak \u00fczere ciddi doku hasar\u0131 izlenmi\u015f, propolisin \u00f6nce verildi\u011fi gruplarda bu hasar\u0131n azald\u0131\u011f\u0131 g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Ayr\u0131ca LPS uygulamas\u0131, mast h\u00fccre say\u0131s\u0131n\u0131 da kontrol grubuna g\u00f6re anlaml\u0131 bir \u015fekilde art\u0131rm\u0131\u015ft\u0131r. LPS uygulamas\u0131, Malondialdehit (MDA) d\u00fczeylerini kontrole g\u00f6re anlaml\u0131 bir \u015fekilde y\u00fckseltmi\u015f propolis verilmesi ise bu art\u0131\u015f\u0131 hafifletmi\u015ftir. Doku \u00f6rneklerinden elde edilen DNA&#8217;lar da Global DNA metilasyon d\u00fczeyi de LPS uygulamas\u0131 ile azal\u0131rken propolis verilen gruplarda kontrole yak\u0131n bulunmu\u015ftur. Kan \u00f6rneklerinde RAPD profilleri arac\u0131l\u0131\u011f\u0131 ile genomik stabilite de\u011ferleri (GTS) incelenmi\u015f ve LPS&#8217;nin genomik stabiliteyi azaltt\u0131\u011f\u0131, tek ba\u015f\u0131na propolis verilen grupta genomik stabilite de\u011ferinin kontrolle ayn\u0131 oldu\u011fu ve LPS uygulamas\u0131ndan \u00f6nce propolis verilen gruplarda genomik stabilite de\u011ferlerinin tekrar artt\u0131\u011f\u0131 g\u00f6r\u00fclm\u00fc\u015ft\u00fcr.\u000bBu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131 LPS ile olu\u015fturulan endotoksemi sonucunda karaci\u011fer de olu\u015fan hasara kar\u015f\u0131 propolisin koruyucu rol\u00fcn\u00fcn oldu\u011funu g\u00f6stermi\u015ftir.<\/p>\n<p><strong>Anahtar Kelimeler: <\/strong>Endotoksemi, LPS, Karaci\u011fer, Propolis, MDA, GTS<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Z\u00fcleyha Do\u011fanyi\u011fit Doktora Tezi, Erciyes \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Histoloji ve Embriyoloji Anabilim Dal\u0131, 2012, 104s. TEZ NO: 311320<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[36],"tags":[163,115,351,298],"class_list":["post-17591","post","type-post","status-publish","format-standard","","category-doktora-tezleri","tag-apiterapi-2","tag-propolis","tag-propolis-ve-karaciger","tag-zuleyha-doganyigit","yazarlar-zuleyha-doganyigit","anahtarkelimeler-apiterapi","anahtarkelimeler-karaciger-hasari","anahtarkelimeler-propolis","anahtarkelimeler-propolisin-faydalari"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17591"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17591\/revisions"}],"predecessor-version":[{"id":17592,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17591\/revisions\/17592"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}