{"id":17561,"date":"2014-10-21T22:50:16","date_gmt":"2014-10-21T19:50:16","guid":{"rendered":"http:\/\/balarisi.org\/?p=17561"},"modified":"2015-03-30T22:12:04","modified_gmt":"2015-03-30T19:12:04","slug":"curuk-gelisimi-uzerine-turk-propolisinin-in-vitro-ve-in-vivo-etkisinin-incelenmesi","status":"publish","type":"post","link":"https:\/\/www.beyazkovan.com\/?p=17561","title":{"rendered":"\u00c7\u00fcr\u00fck geli\u015fimi \u00fczerine T\u00fcrk propolisinin in vitro ve in vivo etkisinin incelenmesi"},"content":{"rendered":"<p><strong>Soley Arslan<\/strong><br \/>\nDoktora Tezi, Erciyes \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Di\u015f Hastal\u0131klar\u0131 ve Tedavisi Anabilim Dal\u0131, 2009, 91 s.<br \/>\nTEZ NO: 247582<br \/>\n<!--more--><span style=\"color: #ff6600;\"><a style=\"color: #ff6600;\" href=\"https:\/\/tez.yok.gov.tr\/UlusalTezMerkezi\/tarama.jsp\" target=\"_blank\">Sorgu Penceresine TEZ NO&#8217;yu yazarak Ayr\u0131nt\u0131l\u0131 Bilgi ve PDF d\u00f6k\u00fcmana ula\u015fmak i\u00e7in t\u0131klay\u0131n\u0131z <\/a><\/span><\/p>\n<p><strong>\u00d6ZET<br \/>\n<\/strong>Propolis ar\u0131lar taraf\u0131ndan \u00fcretilen re\u00e7ine i\u00e7eren bir maddedir. \u00c7ok say\u0131da biyolojik aktiviteye sahip olan propolisin di\u015f \u00e7\u00fcr\u00fc\u011f\u00fcn\u00fcn kontrol\u00fcnde potansiyel uygulamalar\u0131yla ilgili baz\u0131 ara\u015ft\u0131rmalar mevcuttur. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131 T\u00fcrk propolisinin \u00e7\u00fcr\u00fck geli\u015fimi \u00fczerine in vitro ve in vivo etkisini de\u011ferlendirmekti.\u000b\u00c7al\u0131\u015fman\u0131n in vitro b\u00f6l\u00fcm\u00fcnde; propolis etanol, metanol, kloroform, hekzan, etil asetat, ve propilen glikol ile fraksiyonlar\u0131na ayr\u0131ld\u0131. Propilen glikol d\u0131\u015f\u0131ndaki \u00e7\u00f6z\u00fcc\u00fcler buharla\u015ft\u0131r\u0131larak uzakla\u015ft\u0131r\u0131ld\u0131 ve propolis \u00f6z\u00fctleri elde edildi. \u00d6z\u00fctler % 80 etanolde \u00e7\u00f6z\u00fclerek, propolis + propilen glikol kar\u0131\u015f\u0131m\u0131 ise filtre ka\u011f\u0131d\u0131ndan s\u00fcz\u00fclerek direkt kullan\u0131ld\u0131. Bu \u00f6z\u00fctlerin, in vitro antimikrobiyal aktivitesinin belirlenmesi i\u00e7in mutans grubu streptokoklar\u0131n (Streptococcus mutans ve Streptococus sobrinus) \u00e7o\u011falmas\u0131 ve cam y\u00fczeye tutunmalar\u0131 \u00fczerine etkileri ara\u015ft\u0131r\u0131ld\u0131.\u000b\u0130n vivo \u00e7\u00fcr\u00fck \u00e7al\u0131\u015fmas\u0131nda ise, altm\u0131\u015f Wistar albino di\u015fi rat Streptococcus sobrinus ile enfekte edildi. Kontrol grubu (Grup1) d\u0131\u015f\u0131ndaki ratlar\u0131n di\u015fleri ; propolisin etanol \u00f6z\u00fct\u00fc (Grup 2), propolisin hekzan \u00f6z\u00fct\u00fc (Grup 3), % 0,2 klorhekzidin (Grup 4, pozitif kontrol grubu) ve % 80 etanol (Grup 5) ile g\u00fcnde iki kez f\u0131r\u00e7aland\u0131. Be\u015f hafta sonunda ratlar CO2 asfiksasyonu ile sakrifiye edildi. Sol alt \u00e7eneleri aseptik olarak diseke edilerek dental plaktaki Streptoccocus sobrinus d\u00fczeyi belirlendi. \u00c7\u00fcr\u00fck tayini i\u00e7in sol ve sa\u011f mandibuladaki molar di\u015fler kullan\u0131ld\u0131. \u00c7\u00fcr\u00fck de\u011ferlendirilmesinde Keyes skorlama sistemi kullan\u0131ld\u0131.\u000bPropolisin etanol \u00f6z\u00fct\u00fc, ratlar\u0131n dental pla\u011f\u0131nda bulunan Streptococcus sobrinus say\u0131s\u0131n\u0131 pozitif kontrol grubuna benzer oranda azalt\u0131c\u0131 etki g\u00f6stermi\u015ftir. Propolisin etanol \u00f6z\u00fct\u00fc ve propolisin hekzan \u00f6z\u00fct\u00fc uygulanan gruplar kontrol grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, bu gruplarda d\u00fcz y\u00fczey ve sulkus \u00e7\u00fcr\u00fc\u011f\u00fcn\u00fcn anlaml\u0131 \u015fekilde azald\u0131\u011f\u0131 belirlenmi\u015ftir. Bununla birlikte, propolisin etanol \u00f6z\u00fct\u00fc uygulanan grubun \u00e7\u00fcr\u00fck skoru, propolisin hekzan \u00f6z\u00fct\u00fc uygulanan gruba g\u00f6re rakamsal olarak daha d\u00fc\u015f\u00fck bulunmu\u015ftur.\u000bBu \u00e7al\u0131\u015fma T\u00fcrk propolisinin mutans streptokoklara kar\u015f\u0131 iyi bir in vitro ve in vivo antimikrobiyal aktiviteye sahip oldu\u011funu g\u00f6stermi\u015ftir. \u0130laveten, propolisin di\u015f \u00e7\u00fcr\u00fc\u011f\u00fc olu\u015fumunu engellemede klorhekzidin kadar etkili oldu\u011fu bulunmu\u015ftur.<\/p>\n<p><strong>Anahtar Kelimeler: <\/strong>Antimikrobiyal aktivite; Streptococcus sobrinus; Streptococus mutans; propolis; \u00e7\u00fcr\u00fck<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Soley Arslan Doktora Tezi, Erciyes \u00dcniversitesi \/ Sa\u011fl\u0131k Bilimleri Enstit\u00fcs\u00fc \/ Di\u015f Hastal\u0131klar\u0131 ve Tedavisi Anabilim Dal\u0131, 2009, 91 s. TEZ NO: 247582<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[36],"tags":[163,115,328],"class_list":["post-17561","post","type-post","status-publish","format-standard","","category-doktora-tezleri","tag-apiterapi-2","tag-propolis","tag-soley-arslan","yazarlar-soley-arslan","anahtarkelimeler-apiterapi","anahtarkelimeler-propolis","anahtarkelimeler-propolis-ve-discilik","anahtarkelimeler-propolisin-faydalari"],"_links":{"self":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17561"}],"version-history":[{"count":1,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17561\/revisions"}],"predecessor-version":[{"id":17562,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=\/wp\/v2\/posts\/17561\/revisions\/17562"}],"wp:attachment":[{"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.beyazkovan.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}